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Antigenotoxic prenylated flavonoids from stem bark of Erythrina latissima

Author:
Zarev, Yancho, Foubert, Kenn, Lucia de Almeida, Vera, Anthonissen, Roel, Elgorashi, Esameldin, Apers, Sandra, Ionkova, Iliana, Verschaeve, Luc, Pieters, Luc
Source:
Phytochemistry 2017 v.141 pp. 140-146
ISSN:
0031-9422
Subject:
Erythrina, aflatoxin B1, bark, curcumin, flavonoids, genotoxicity, inhibitory concentration 50
Abstract:
A series of prenylated flavonoids was obtained from antigenotoxic extracts and fractions of stem bark of Erythrina latissima E. Mey (Leguminosae). In addition to five constituents never reported before, i.e. (2S)-5,7-dihydroxy-2-(4-hydroxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)chroman-4-one (erylatissin D), (2S)-5,7-dihydroxy-2-(4-methoxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)chroman-4-one (erylatissin E), 5,7-dihydroxy-3-(4-methoxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)-4H-chromen-4-one (erylatissin F), (2S)-5,7,8′-trihydroxy-2′,2′-dimethyl-[2,6′-bichroman]-4-one (erylatissin G) and (2S)-5,7-dihydroxy-8′-methoxy-2′,2′-dimethyl-[2,6′-bichroman]-4-one (dihydroabyssinin I), 18 known flavonoids were identified. Evaluation of the antigenotoxic properties (against genotoxicity induced by aflatoxin B1, metabolically activated) in the Vitotox assay revealed that most flavonoids were active. Sigmoidin A and B showed the highest activity, with an IC50 value of 18.7 μg/mL, equivalent to that of curcumin (IC50 18.4 μg/mL), used as a reference antigenotoxic compound.
Agid:
5708888