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Antigenotoxic prenylated flavonoids from stem bark of Erythrina latissima
- Zarev, Yancho, Foubert, Kenn, Lucia de Almeida, Vera, Anthonissen, Roel, Elgorashi, Esameldin, Apers, Sandra, Ionkova, Iliana, Verschaeve, Luc, Pieters, Luc
- Phytochemistry 2017 v.141 pp. 140-146
- Erythrina, aflatoxin B1, bark, curcumin, flavonoids, genotoxicity, inhibitory concentration 50
- A series of prenylated flavonoids was obtained from antigenotoxic extracts and fractions of stem bark of Erythrina latissima E. Mey (Leguminosae). In addition to five constituents never reported before, i.e. (2S)-5,7-dihydroxy-2-(4-hydroxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)chroman-4-one (erylatissin D), (2S)-5,7-dihydroxy-2-(4-methoxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)chroman-4-one (erylatissin E), 5,7-dihydroxy-3-(4-methoxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)-4H-chromen-4-one (erylatissin F), (2S)-5,7,8′-trihydroxy-2′,2′-dimethyl-[2,6′-bichroman]-4-one (erylatissin G) and (2S)-5,7-dihydroxy-8′-methoxy-2′,2′-dimethyl-[2,6′-bichroman]-4-one (dihydroabyssinin I), 18 known flavonoids were identified. Evaluation of the antigenotoxic properties (against genotoxicity induced by aflatoxin B1, metabolically activated) in the Vitotox assay revealed that most flavonoids were active. Sigmoidin A and B showed the highest activity, with an IC50 value of 18.7 μg/mL, equivalent to that of curcumin (IC50 18.4 μg/mL), used as a reference antigenotoxic compound.