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Nanoparticle-Based Dressing: The Future of Wound Treatment?
- Berthet, Morgane, Gauthier, Yves, Lacroix, Céline, Verrier, Bernard, Monge, Claire
- Trends in biotechnology 2017
- dermis, drugs, models, nanoparticles, tissue repair, topical application, wound treatment
- Reconstructing functional skin after a wound remains a challenge due to the complexity of healing. In this regard, biocompatible nanoparticles (NPs) carrying and releasing bioactive drugs in a controlled and sustained manner may significantly improve the efficacy of wound therapies compared with current treatments. Topical administration of drug-loaded NPs allows optimal delivery to the dermis and improves product efficacy. Furthermore, associating NPs with scaffolds represents a new concept of ‘dressing’. Experimental in vivo, ex vivo, and in vitro models have been developed in preclinical assays to evaluate the beneficial effects of nanoparticulate dressings. Drug-loaded NPs are promising tools for innovative wound healing treatment, especially with regard to their multifunctional properties.