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Alpha-lipoic acid supplement in obesity treatment: A systematic review and meta-analysis of clinical trials

Namazi, Nazli, Larijani, Bagher, Azadbakht, Leila
Clinical nutrition 2017
adults, antioxidants, body mass index, clinical trials, cost effectiveness, databases, health status, lipoic acid, meta-analysis, obesity, placebos, systematic review, waist circumference, weight loss
Previous studies have supported positive roles of antioxidant supplements on weight-loss. One antioxidant supplement is Alpha- lipoic acid. However, recommending ALA as an anti-obesity supplement remains controversial. Accordingly, the purpose of the present study was to perform a meta-analysis on the effects of ALA supplement on anthropometric indices among adult subjects.We searched five electronic databases till Sep 2016. Placebo-controlled clinical trials were included. Weighted Mean Differences (WMD) was pooled using a random-effects model.Findings of 12 included trials indicated that ALA supplement reduced body weight (WMD: -0.69 kg; 95% CI: -1.27, -0.10, I2=0%) and BMI (WMD: -0.38 kg/m2, 95% CI: -0.53, -0.24, I2= 0%) significantly compared to the placebo group. However, its effects on Waist Circumference (WC) was not significant (WMD: -0.30 cm, 95% CI: -1.18, 0.58, I2=17.8%). Stratification by health status indicated that ALA decreased WC in unhealthy subjects (WMD: -2.00 cm, 95% CI: -4.19, 0.19, I2=1.3%) more than healthy individuals (0.03 cm, 95% CI:-0.69, 0.75 I2=0%).The present study revealed that supplementation with ALA slightly but significantly decreased body weight and BMI. Safe dosage for ALA is up to 1200 mg/day. However, it seems that ALA cannot be cost-effective. Further studies are needed to clarify the effects of ALA on metabolic parameter in unhealthy obese individuals.