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Four new iridoid glucosides containing the furan ring from the fruit of Cornus officinalis

Author:
Jun He, Xian-Sheng Ye, Xiao-Xue Wang, Ya-Nan Yang, Pei-Cheng Zhang, Bing-Zhi Ma, Wei-Ku Zhang, Jie-Kun Xu
Source:
Fitoterapia 2017 pp. -
ISSN:
0367-326X
Subject:
Cornus officinalis, chemical structure, circular dichroism spectroscopy, glucosides, iridoid glycosides, neuroprotective effect, nuclear magnetic resonance spectroscopy, spectral analysis, sugars
Abstract:
Four new and rare iridoid glucosides, cornusfuroside A–D (1–4), containing the furan ring were identified from water extract of the fruit of Cornus officinalis. These new chemical structures were determined through extensive spectroscopic analysis, including 1D and 2D NMR, IR, HRESIMS, experimental and calculated electronic circular dichroism (ECD). Notably, this study is the first report on the isolation of four iridoid glucoside structures with acetal functions in the sugar moiety. The neuroprotective effects of these compounds were also evaluated in vitro.
Agid:
5710321