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Gelsedine-type oxindole alkaloids from Gelsemium elegans and the evaluation of their cytotoxic activity

Author:
Wang, Lei, Wang, Jin-Feng, Mao, Xia, Jiao, Li, Wang, Xiao-Jun
Source:
Fitoterapia 2017
ISSN:
0367-326X
Subject:
Gelsemium, alkaloids, branches, cytotoxicity, ethanol, inhibitory concentration 50, leaves, mass spectrometry, neoplasm cells, nuclear magnetic resonance spectroscopy
Abstract:
Phytochemical investigation on the 70% EtOH extract of the leaves and branches of Gelsemium elegans resulted into the isolation of five new gelsedine-type oxindole alkaloids, gelseleganins A–E (1–5). The structures of the isolated compounds were established based on 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated alkaloids were tested in vitro for cytotoxic potential against seven tumor cell lines. As a result, alkaloids 3 exhibited significant cytotoxic activities against all the tested tumor cell lines with IC50 values <10μM.
Agid:
5710323