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Antiviral activity of Ellagic acid and Annona Muricata in cervical HPV related pre-neoplastic lesions: A randomized trial
- Le Donne, Maria, Lentini, Maria, Alibrandi, Angela, Salimbeni, Vincenzino, Giuffre', Giuseppe, Mazzeo, Francesca, Triolo, Onofrio, D'Anna, Rosario
- Journal of functional foods 2017 v.35 pp. 549-554
- Annona muricata, antioxidants, antiviral properties, ellagic acid, humans, models, oncogene proteins, papilloma, placebos, risk, viruses, women
- Ellagic acid (EA) and Annona Muricata (AM) have antioxidant, anticarcinogenic and antiviral activity demonstrated by in vitro models. This pilot study investigated the in vivo potential anti-viral activity in women affected by Low squamous intraepithelial lesion (L-SIL) related to high risk human papilloma virus (HR-HPV), and the ability to modify the oncoproteins expression in the cervical lesion thickness. Sixty women affected by HR-HPV related L-SIL, were randomly divided into two groups: group A (n=30) supplemented with EA (16mg)+AM (100mg) 2 times daily for 6months and group B (n=30) administered with placebo. HR-HPV clearance was obtained in 74% of cases in group A compared to 25% of cases in group B (p=0.001) and p21 expression in LSIL thickness increased in 63.2% of cases in group A compared to 20% in group B (p=0.03). AE/AM supplementation significantly induces HR-HPV elimination and stimulates p21 expression in LSIL thickness.