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Postvaccination wounds associated predominantly with Arcanobacterium phocae in mink (Neovison vison) at three mink farms

Molenaar, Robert J., Buter, Rianne, Sroka, Agnieszka
Veterinary dermatology 2017 v.28 no.2 pp. 242
Arcanobacterium phocae, Neovison vison, dermatitis, farms, intergenic DNA, mink, pathogenesis, pyoderma, ribosomal DNA, risk factors, vaccination, vaccines
BACKGROUND: The emerging skin disease fur animal epidemic necrotic pyoderma (FENP) has been attributed to infection with Arcanobacterium phocae (ABP). The exact pathogenesis and risk factors of FENP have yet to be elucidated. ANIMALS: Three mink from each of three different mink farms (A–C) with postvaccination skin wounds at the vaccination site and six mink from an unaffected mink farm (D) that had used the same vaccine batch and vaccination site (hind leg). METHODS AND RESULTS: All mink from farms A–C had severe necrotizing to necropurulent dermatitis where they were vaccinated intramuscularly in the hind leg. ABP was the sole bacterium cultured from six of nine wounds. Using 16S–23S rDNA intergenic spacer region and BOX‐PCR, the ABP isolates from these wounds were indistinguishable from isolates originating from several cases of FENP. CONCLUSIONS AND CLINICAL IMPORTANCE: This is the first report of FENP‐like lesions at the site of vaccination, in the days following the procedure, associated with ABP. At farms with FENP vaccination, procedures should be considered carefully.