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Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism

Author:
Al-Askar, Maha, Bhat, RamesaShafi, Selim, Manar, Al-Ayadhi, Laila, El-Ansary, Afaf
Source:
BMC complementary and alternative medicine 2017 v.17 no.1 pp. 259
ISSN:
1472-6882
Subject:
albino, alternative medicine, animal models, autism, brain, brain damage, clinical trials, curcumin, dietary supplements, fetus, glutamic acid, glutamine, glutathione, glutathione transferase, humans, interferon-gamma, interleukin-6, lipids, males, mothers, neonates, oxidation, peroxidase, pregnancy, progeny, rats, serotonin, toxicity, valproic acid
Abstract:
BACKGROUND: Valproic acid (VPA) is used as a first-line antiepileptic agent and is undergoing clinical trials for use as a treatment for many disorders. Mothers undergoing VPA treatment during early pregnancy reportedly show increased rates of autism among their offspring. The benefits of curcumin supplementation were investigated using an animal model of VPA-induced autism. METHODS: The study was performed using a rodent model of autism by exposing rat fetuses to valproic acid (VPA) on the 12.5th day of gestation. At 7 days from their birth, the animals were supplemented with a specific dose of curcumin. Forty neonatal male Western Albino rats were divided into four groups. Rats in group I received only phosphate-buffered saline, rats in group II were the prenatal VPA exposure newborns, rats in group III underwent prenatal VPA exposure supplemented with postnatal curcumin, and rats in group IV were given only postnatal curcumin supplements. RESULTS: VPA rats exhibited delayed maturation and lower body and brain weights with numerous signs of brain toxicity, such as depletion of IFN-γ, serotonin, glutamine, reduced glutathione, glutathione S-transferase, lipid peroxidase with an increase in CYP450, IL-6, glutamate, and oxidized glutathione. A curcumin supplement moderately corrected these dysfunctions and was especially noticeable in improving delayed maturation and abnormal weight. CONCLUSIONS: Curcumin plays a significant therapeutic role in attenuating brain damage that has been induced by prenatal VPA exposure in rats; however, its therapeutic role as a dietary supplement still must be certified for use in humans.
Agid:
5728760