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Role of systemic injection of rabies immunoglobulin in rabies vaccination

Author:
Wu, Weichen, Liu, Shuqing, Yu, Pengcheng, Tao, Xiaoyan, Lu, Xuexin, Yan, Jianghong, Wang, Qian, Zhang, Zongshen, Zhu, Wuyang
Source:
Archives of virology 2017 v.162 no.6 pp. 1701-1703
ISSN:
0304-8608
Subject:
Rabies virus, antibodies, blood serum, immunoglobulins, mice, neutralization, rabies, vaccination, vaccines
Abstract:
To determine the role of systemic injection of rabies immunoglobulin (RIG) in rabies vaccination, we analyzed the level of antibody against rabies virus in the serum of mice that received various doses of RIG combined with rabies vaccine. Our results indicate that systemic injection of RIG does not contribute detectably to passive or adaptive immunization, suggesting that the main function of RIG in individuals with category III exposure is to neutralize rabies virus via immediate local infiltration of the wound.
Agid:
5728853