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Terpenoids from Curcuma wenyujin increased glucose consumption on HepG2 cells

Author:
Zhou, Chang-Xin, Zhang, Li-Sha, Chen, Fei-Fei, Wu, Hao-Shu, Mo, Jian-Xia, Gan, Li-She
Source:
Fitoterapia 2017
ISSN:
0367-326X
Subject:
Curcuma, ethanol, glucose, human cell lines, models, nuclear magnetic resonance spectroscopy, petroleum, sesquiterpenoids, tubers
Abstract:
Thirty four terpenoids, including two new cadinane-type sesquiterpenoids containing conjugated aromatic-ketone moieties, curcujinone A (1) and curcujinone B (2), were isolated from 95% ethanol extract of the root tubers of Curcuma wenyujin. Their structures were determined by spectroscopic methods, especially 2D NMR and HRMS techniques. The relative and absolute configurations of 1 and 2 were identified by quantum chemical DFT and TDDFT calculations of the 13C NMR chemical shifts, ECD spectra, and specific optical rotations. All compounds and extracts were evaluated for their anti-diabetic activities with a glucose consumption model on HepG2 Cells. The petroleum fraction CWP (10μg/mL) and compounds curcumenol (4), 7α,11α-epoxy-5β-hydroxy-9-guaiaen-8-one (5), curdione (17), (1S, 4S, 5S 10S)-germacrone (18), zederone (20), a mixture of curcumanolide A (25) and curcumanolide B (26), gajutsulactone B (27), and wenyujinin C (30) showed promising activities with over 45% increasing of glucose consumption at 10μM.
Agid:
5730250