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For Certain, SIRT4 Activities!
- Kumar, Surinder, Lombard, David B.
- Trends in biochemical sciences 2017 v.42 no.7 pp. 499-501
- enzyme activity, leucine, lysine, metabolism
- Despite the fact that SIRT4 regulates important biological processes, its primary enzymatic activity has remained ambiguous. A recent study by Anderson, Huynh et al. has uncovered deacylase activities of SIRT4 towards newly described lysine modifications derived from reactive acyl-CoAs generated in leucine catabolism.