Main content area

Three new benzolactones from Lavandula angustifolia and their bioactivities

Shi, Jian-Lian, Tang, Shi-Yun, Liu, Chun-Bo, Ye, Ling, Yang, Pei-Song, Zhang, Feng-Mei, He, Pei, Liu, Zhi-Hua, Miao, Ming-Ming, Guo, Ya-Dong, Shen, Qin-Peng
Journal of Asian natural products research 2017 v.19 no.8 pp. 766-773
Lavandula angustifolia, antiviral properties, cytotoxicity, humans, inhibitory concentration 50, neoplasm cells, nuclear magnetic resonance spectroscopy, spectral analysis, viruses
Three new benzolactones (1 – 3), together with four known ones (4 – 7), were isolated from the whole herb of Lavandula angustifolia . Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New compounds were evaluated for their anti-tobacco mosaic virus (TMV) activities and cytotoxic activities. The results revealed that compounds 1 – 3 showed obvious anti-TMV activities with inhibition rates of 26.9, 30.2, and 28.4%, which were at the same grade as positive control. Compounds 1 – 3 also showed weak inhibitory activities against some tested human tumor cell lines with IC ₅₀ values in the range of 32.1–7.6 μM.