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Novel DNA/RNA-targeting amino acid beacon for the versatile incorporation at any position within the peptide backbone
- Šmidlehner, Tamara, Piantanida, Ivo
- Amino acids 2017 v.49 no.8 pp. 1381-1388
- amino acids, fluorescent dyes, fluorometry
- One-pot tandem synthesis was for the first time applied to attach fluorophore to the amino acid side chain, yielding amino acid ready for peptide coupling at the N-terminus, and also upon activation at the C-terminus. Two new compounds differing only in fluorophore-linker length showed exceptional fluorimetric and CD recognition between DS-RNA and DS-DNA, thus being promising beacons for versatile peptide incorporation.