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Extracts of Mauritian Carica papaya (var. solo) protect SW872 and HepG2 cells against hydrogen peroxide induced oxidative stress

Somanah, Jhoti, Bourdon, Emmanuel, Bahorun, Theeshan
Journal of food science and technology 2017 v.54 no.7 pp. 1917-1927
Carica papaya, antioxidant activity, chemokine CCL2, fruit extracts, hepatoma, human cell lines, humans, hydrogen peroxide, inflammation, interleukin-6, mitochondria, models, neoplasm cells, oxidative stress, papayas, tumor necrosis factor-alpha, viability
In line with literature documenting the pluripotent activities of tropical fruits, this study evaluated the antioxidant effects of Carica papaya fruit extracts at cellular level. Investigations using cellular models of oxidative stress provided complementary evidence of the antioxidant activities of papaya fruit. At 2 mg dry weight ml⁻¹, extracts of seed from ripe and unripe fruit significantly reduced oxidative stress levels within human pre-adipocytes (SW872) and hepatocellular carcinoma cells (HepG2) exposed to hydrogen peroxide (H₂O₂). Maintenance of mitochondrial viability, reduction of intracellular reactive oxygen species levels and mediation of pro-inflammatory cytokine secretory levels (tumour necrosis factor-α, interleukin-6, monocyte chemoattractant protein-1) were all indicative of its cytoprotective effects against oxidative-inflammation. This work demonstrates that the Mauritian Solo papaya is an important source of natural antioxidants that could be used for the dietary modulation of oxidative stress and inflammation.