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The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats

Kiełczykowska, Małgorzata, Musik, Irena, Kurzepa, Jacek, Żelazowska, Renata, Lewandowska, Anna, Paździor, Marek, Kocot, Joanna
Biological trace element research 2017 v.178 no.1 pp. 79-85
adjuvants, adverse effects, brain, calcium, heart, homeostasis, kidneys, lithium, liver, magnesium, medicine, muscles, rats, selenium, silicon, spleen, stomach, therapeutics
Lithium is widely used in medicine and the therapy is often long term. Apart from beneficial effects, its application can cause diverse side effects. The current study was performed with the aim of the evaluation of the effect of lithium and/or selenium administration on magnesium, calcium and silicon levels in rats. The study was performed on rats divided into four groups (six animals each): control—received saline, Li—received Li₂CO₃ (2.7 mg Li/kg b.w.), Se—received Na₂SeO₃·H₂O (0.5 mg Se/kg b.w.), and Li+Se—received simultaneously Li₂CO₃ and Na₂SeO₃·H₂O (2.7 and 0.5 mg Se/kg b.w.). The administration was performed in form of water solutions by a stomach tube once a day for 6 weeks. In the organs (liver, kidney, brain, spleen, heart, lung and femoral muscle), the concentrations of magnesium, calcium and silicon were determined. Lithium significantly increased Ca in the kidney, brain and spleen. Coadministration of selenium reversed this effect. No changes of magnesium in organs were observed. Silicon was affected only in spleen—an increase vs. control was observed in all studied groups. The beneficial influence of coadministration of selenium in case of calcium lets us suggest that an issue of its possible use as an adjuvant alleviating side effects in lithium-treated subjects is worth being continued.