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Effects of Zinc Supplementation on DNA Damage in Rats with Experimental Kidney Deficiency

Author:
Yegin, Sevim Çiftçi, Dede, Semiha, Mis, Leyla, Yur, Fatmagül
Source:
Biological trace element research 2017 v.176 no.2 pp. 338-341
ISSN:
0163-4984
Subject:
DNA damage, dietary mineral supplements, kidneys, rats, renal failure, zinc
Abstract:
This study was carried out to determine the effect of zinc on oxidative DNA damage in rats with experimental acute and chronic kidney deficiency. Six groups of five Wistar-Albino rats each were assigned as controls (C), acute kidney deficiency (AKD), zinc-supplemented (+Zn), acute kidney deficiency, zinc-supplemented (AKD + Zn), chronic kidney deficiency (CKD) and zinc-supplemented chronic kidney deficiency (CKD + Zn). The levels of 8-Oxo-2′-deoxyguanosine (8-OHdG) were determined, being the lowest in the CKD group (p < 0.05), higher in the C group than those of rats with CKD but lower than that of all the other groups (p < 0.05). There were no significant differences between the controls and the CKD + Zn group, or between the AKD and the +Zn groups. Among all groups, the highest 8-OHdG level was found in the AKD + Zn group (p < 0.05). DNA damage was greater in acute renal failure than in rats with chronic renal failure. The DNA damage in the zinc group was significantly higher than in the controls.
Agid:
5757138