Main content area

Biofungicide utilizations of antifungal proteins of filamentous ascomycetes: current and foreseeable future developments

Leiter, Éva, Gáll, Tamás, Csernoch, László, Pócsi, István
BioControl 2017 v.62 no.2 pp. 125-138
Ascomycota, antifungal agents, antifungal proteins, biological control, biopesticides, fungi, host plants, mammals, manufacturing, molecular weight
Today’s dearth of effective antimicrobial agents can be overcome by the use of antimicrobial proteins, which are produced naturally by a wide range of organisms including microorganisms, plants and mammals. These small basic proteins are highly stable, easy to manufacture on a large scale, and any resistance against them develops only rarely. These proteins are therefore good candidates for the treatment and prevention of various fungal infections. Importantly, these protein-based antimycotics can even be expressed heterologously in suitable organisms and can be used for various agricultural purposes in the future including biocontrol applications. In this review, we summarize today’s knowledge on the sources, structures, large-scale productions, direct surface applications as well as on the heterologous expressions in host plants of the small molecular mass antifungal proteins produced by filamentous fungi. Future developments foreseeable in this promising area of antifungal protein research are also presented and discussed in this review.