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A New 2H-Pyran-2-One Derivative and Anti-inflammatory Constituents of Alpinia zerumbet

Author:
Chen, Jih-Jung, Liao, Hsiang-Ruei, Chen, Keh-Shaw, Cheng, Ming-Jen, Shu, Chih-Wen, Sung, Ping-Jyun, Lim, Yun-Ping, Wang, Tai-Chi, Kuo, Wen-Lung
Source:
Chemistry of natural compounds 2017 v.53 no.1 pp. 40-43
ISSN:
0009-3130
Subject:
Alpinia zerumbet, chemistry, inhibitory concentration 50, quercetin, rhizomes, superoxide anion
Abstract:
A new 2H-pyran-2-one derivative, 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one (1), together with four known compounds, 5,6-dehydrokawain (2), dihydro-5,6-dehydrokawain (3), (E)-labda-8(17),12-diene-15,16-dial (4), and quercetin (5) were isolated from the rhizomes of Alpinia zerumbet. (E)-Labda-8(17),12-diene-15,16-dial (4) and quercetin (5) exhibited potent inhibition, with IC₅₀ values of 3.18 ± 1.13 and 1.17 ± 0.13 μg/mL, respectively, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O ₂ ⁻) generation.
Agid:
5758439