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Zinc Sulfate and/or Growth Hormone Administration for the Prevention of Radiation-Induced Dermatitis: a Placebo-Controlled Rat Model Study
- Kandaz, Mustafa, Ertekin, Mustafa Vecdi, Karslıoğlu, İhsan, Erdoğan, Fazlı, Sezen, Orhan, Gepdiremen, Akçahan, Gündoğdu, Cemal
- Biological trace element research 2017 v.179 no.1 pp. 110-116
- animal models, atrophy, dermatitis, gamma radiation, hair follicles, irradiation, legs, radiation injury, rats, somatotropin, subcutaneous injection, zinc, zinc sulfate
- Growth hormone (GH) and zinc (Zn) were evaluated for their potential to prevent radiation injury using a rat model of radiation-induced skin injury. Sprague–Dawley rats were divided into five groups: a control group not receiving Zn, GH, or irradiation: a radiation (RT) group receiving a single 30 Gy dose of gamma irradiation to the right hind legs; a radiation + GH group (RT + GH) receiving a single 30 Gy dose of gamma irradiation plus the subcutaneous administration of 0.01 IU kg d⁻¹ GH; a radiation + Zn group (RT + Zn) receiving a single 30 Gy dose plus 5 mg kg d⁻¹ Zn po; and a radiation + GH + Zn group (RT + GH + Zn) group receiving a single 30 Gy dose plus subcutaneous 0.01 IU kg d⁻¹ GH and 5 mg kg d⁻¹ Zn po. Acute skin reactions were assessed every 3 days by two radiation oncologists grouping. Light microscopic findings were assessed blindly by two pathologists. Groups receiving irradiation were associated with dermatitis as compared to the control group (P < 0.05). The severity of radiodermatitis in the RT + GH, RT + Zn, and RT + GH + Zn groups was significantly lower than that in the RT group (P < 0.05). Furthermore, radiodermatitis was observed earlier in the RT group than in the other treatment groups (P < 0.05). GH and Zn effectively prevented epidermal atrophy, dermal degeneration, and hair follicle atrophy. The highest level of protection against radiation dermatitis was observed in the combination group.