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Der Einfluß von D-Penicillamin auf den Gehalt einiger Organe an Spurenelementen sowie auf die mechanischen Eigenschaften von Kollagen / Trace Elements in Several Organs and Mechanical Properties of Collagen under the Influence of D-Penicillamin
- Wesch, H., Jonak, R., Nemetschek-Gansler, H., Riedl, H., Nemetschek, Th.
- Zeitschrift für Naturforschung 1978 v.33 no.5-6 pp. 346-358
- cobalt, collagen, copper, iron, manganese, rats, schiff bases, tail, thermal stability, zinc
- The content of trace elements in several organs of rats under the influence of D-penicillamine (D-PA) was investigated by the neutronactivation-analysis. It could be shown an diminution of Cu, and Co under D-PA-treatment, the content of Fe, Mn, Rb and Zn was not influenced. The investigat ed organs didn’t show any submicroscopic alterations under D-PA. On isolated collagen fibrils of tail tendon was seen a significantly diminuition of E-moduls. In accordance with Siegel the principal effect of D-PA is thought to block the synthesis of functional groups from Schiff-base crosslink precursors but not to inhibit lysyloxidase by loss of Cu-ions of connective tissue. The thermostability of D-PA influenced fibrils is changed in stretched state only and will be due to the lack of crosslink Schiff-bases; where as the shrinking point of not stretched fibrils shows only aging dependent changes.