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Zinc-Triggered Hierarchical Self-Assembly of Fibrous Helix–Loop–Helix Peptide Superstructures for Controlled Encapsulation and Release

Author:
Aronsson, Christopher, Selegård, Robert, Aili, Daniel
Source:
Macromolecules 2016 v.49 no.18 pp. 6997-7003
ISSN:
1520-5835
Subject:
drugs, encapsulation, nanoparticles, zinc
Abstract:
We demonstrate a novel route for hierarchical self-assembly of sub-micrometer-sized peptide superstructures that respond to subtle changes in Zn²⁺ concentration. The self-assembly process is triggered by a specific folding-dependent coordination of Zn²⁺ by a de novo designed nonlinear helix–loop–helix peptide, resulting in a propagating fiber formation and formation of spherical superstructures. The superstructures further form larger assemblies that can be completely disassembled upon removal of Zn²⁺ or degradation of the nonlinear peptide. This flexible and reversible assembly strategy of the superstructures enables facile encapsulation of nanoparticles and drugs that can be released by means of different stimuli.
Agid:
5782333