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Efficient Generation of ortho-Quinone Methide: Application to the Biomimetic Syntheses of (±)-Schefflone and Tocopherol Trimers
- Liao, Daohong, Li, Houhua, Lei, Xiaoguang
- Organic letters 2012 v.14 no.1 pp. 18-21
- oxidation, silver oxide, synthesis
- An efficient method using silver oxide-mediated oxidation for the synthesis of ortho-quinone methides has been developed and applied to the biomimetic syntheses of novel trimeric natural products, (±)-schefflone and tocopherol trimers. Further studies of the critical trimerization as well as substrate scope and limitations are also reported.