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Ruthenium-Catalyzed Highly Regioselective Cyclization of Ketoximes with Alkynes by C–H Bond Activation: A Practical Route to Synthesize Substituted Isoquinolines

Author:
Chinnagolla, Ravi Kiran, Pimparkar, Sandeep, Jeganmohan, Masilamani
Source:
Organic letters 2012 v.14 no.12 pp. 3032-3035
ISSN:
1523-7052
Subject:
alkynes, carbon-hydrogen bond activation, chemical bonding, chemical reactions, chemical structure, isoquinolines, p-cymene, regioselectivity
Abstract:
Aromatic and heteroaromatic ketoximes underwent cyclization with alkynes in the presence of a catalytic amount of [{RuCl₂(p-cymene)}₂] and NaOAc to give isoquinoline derivatives in good to excellent yields in a highly regioselective manner.
Agid:
5783915