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Palladium-Catalyzed Hiyama Couplings of α-Silylenoates and α-Silylenamides
- Rooke, Douglas A., Ferreira, Eric M.
- Organic letters 2012 v.14 no.13 pp. 3328-3331
- alkenes, catalytic activity, chemical reactions, chemical structure, palladium, regioselectivity, silver
- The Hiyama couplings of both α-silylenoates and α-silylenamides are described. These sensitive substrate classes require particularly specific conditions, employing both appropriate silicon-based species and a silver additive to realize high yields of the coupling products. Regioselective platinum-catalyzed hydrosilylations provide a direct and convenient entry into these stereodefined trisubstituted alkenes.