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Rhodium(III)-Catalyzed Cyclization–Olefination of N-Acetoxyl Ketoimine-Alkynes

Author:
Zhao, Peng, Wang, Fen, Han, Keli, Li, Xingwei
Source:
Organic letters 2012 v.14 no.13 pp. 3400-3403
ISSN:
1523-7052
Subject:
alkynes, chemical reactions, isoquinolines, moieties, rhodium
Abstract:
N-Acetoxyl ketoimine-alkynes undergo Rh(III)-catalyzed oxidative olefination to afford (2-acetoxymethyl)isoquinolines bearing an ortho-olefinated aryl group via a sequence that involves (1) Rh(III)-catalyzed alkyne cyclization with intramolecular 1,3-acetoxyl migration and (2) isoquinoline-directed ortho C–H olefination.
Agid:
5784015