PubAg

Main content area

Unprecedented Meta-Substitution of Calixarenes: Direct Way to Inherently Chiral Derivatives

Author:
Slavik, Petr, Dudic, Miroslav, Flidrova, Karolina, Sykora, Jan, Cisarova, Ivana, Böhm, Stanislav, Lhotak, Pavel
Source:
Organic letters 2012 v.14 no.14 pp. 3628-3631
ISSN:
1523-7052
Subject:
Lewis acids, aromatic hydrocarbons, chemical reactions, chemical structure, regioselectivity
Abstract:
Electrophilic aromatic substitution in the calix[n]arene series is a well-established procedure leading exclusively to para-substituted derivatives. An unprecedented regioselectivity of the mercuration reaction leading to the meta-substituted calix[4]arenes is described. These compounds represent a new type of substitution pattern in classical calixarene chemistry and open the door for the straightforward synthesis of inherently chiral receptors based on calixarenes.
Agid:
5784070