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Biomimetic Flavin-Catalyzed Aldehyde Oxidation

Author:
Murray, Alexander T., Matton, Pascal, Fairhurst, Nathan W. G., John, Matthew P., Carbery, David R.
Source:
Organic letters 2012 v.14 no.14 pp. 3656-3659
ISSN:
1523-7052
Subject:
aldehydes, biomimetics, byproducts, carboxylic acids, catalysts, chemical structure, hydrogen peroxide, oxidation, solvents
Abstract:
The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.
Agid:
5784078