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Ni-Catalyzed Alkenylation of Triazolopyridines: Synthesis of 2,6-Disubstituted Pyridines

Author:
Liu, Sheng, Sawicki, James, Driver, Tom G.
Source:
Organic letters 2012 v.14 no.14 pp. 3744-3747
ISSN:
1523-7052
Subject:
chemical reactions, chemical structure, nitrogen, pyridines, regioselectivity
Abstract:
A synthetic strategy to access 2,6-disubstituted pyridines from triazolopyridines through a regioselective nickel-catalyzed alkenylation reaction of the C7–H bond is described. The N₂ fragment embedded in the resulting C–H functionalized triazolopyridine can be readily excised using acidic or oxidative conditions to unmask the pyridine.
Agid:
5784103