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Lewis Acid Catalyzed α-Functionalization of Ketals for the Regioselective Synthesis of α-Carbamoyl Ketals

Author:
Magnus, Philip, Brozell, Alec J.
Source:
Organic letters 2012 v.14 no.15 pp. 3952-3954
ISSN:
1523-7052
Subject:
Lewis acids, chemical reactions, chemical structure, organic compounds, regioselectivity
Abstract:
Treatment of 1 with DEAD in the presence of BF₃·OEt₂ gave 2 (R = H), which was N-alkylated to give 2 (R = CH₂CO₂Et), and insitu eliminated (E1cb) to give α-carbamoyl ketals.
Agid:
5784153