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Studies toward the Synthesis of Spirolide C: Exploration into the Formation of the 23-Membered All-Carbon Macrocyclic Framework
- Stivala, Craig E., Gu, Zhenhua, Smith, Lindsay L., Zakarian, Armen
- Organic letters 2012 v.14 no.3 pp. 804-807
- aldehydes, chemical reactions, chemical structure
- The synthesis of two complex subunits en route to spirolide C is described. A key alkyllithium addition to an aldehyde joins the fragments, which are advanced in order to investigate a ring-closing metathesis to form the 23-membered all-carbon macrocyclic framework.