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Intramolecular Pd(II)-Catalyzed Aerobic Oxidative Amination of Alkenes: Synthesis of Six-Membered N-Heterocycles

Author:
Lu, Zhan, Stahl, Shannon S.
Source:
Organic letters 2012 v.14 no.5 pp. 1234-1237
ISSN:
1523-7052
Subject:
alkenes, amination, catalysts, chemical structure, dimethyl sulfoxide, morpholines, nitrogen, piperazines, piperidines, sulfonamides
Abstract:
Use of a base-free Pd(DMSO)₂(TFA)₂ catalyst system enables the synthesis of six-membered nitrogen heterocycles via a Wacker-type aerobic oxidative cyclization of alkenes bearing tethered sulfonamides. Various heterocycles, including morpholines, piperidines, piperazines, and piperazinones, are accessible by this method.
Agid:
5784967