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Neaumycin: A New Macrolide from Streptomyces sp. NEAU-x211

Author:
Huang, Sheng-Xiong, Wang, Xiang-Jing, Yan, Yijun, Wang, Ji-Dong, Zhang, Ji, Liu, Chong-Xi, Xiang, Wen-Sheng, Shen, Ben
Source:
Organic letters 2012 v.14 no.5 pp. 1254-1257
ISSN:
1523-7052
Subject:
Streptomyces, chemical reactions, chemical structure, macrolides, nuclear magnetic resonance spectroscopy, soil, spectral analysis, stereochemistry
Abstract:
Neaumycin, a new 30-membered macrolide featuring an internal diester bridge, a molecular architecture that is unprecedented among known macrolide natural products, was isolated from a soil actinomycete strain Streptomyces sp. NEAU-x211. The structure of neaumycin was elucidated on the basis of comprehensive mass and NMR spectroscopic interpretation, including the relative stereochemistry of four independent coupling systems.
Agid:
5784972