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Steric Parameters in the Ir-Catalyzed Regio- and Diastereoselective Isomerization of Primary Allylic Alcohols

Author:
Li, Houhua, Mazet, Clément
Source:
Organic letters 2013 v.15 no.24 pp. 6170-6173
ISSN:
1523-7052
Subject:
Gibbs free energy, alcohols, catalysts, chemical structure, diastereoselectivity, isomerization, regioselectivity
Abstract:
The iridium-catalyzed diastereo- and regioselective isomerization of primary allylic alcohols using Crabtree’s catalyst or sterically modified analogs is reported. The importance of the size of the substituents on either the substrates or the catalysts has been rationalized by linear free energy relationships.
Agid:
5786341