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Catalytic Antioxidants: Regenerable Tellurium Analogues of Vitamin E
- Singh, Vijay P., Poon, Jia-fei, Engman, Lars
- Organic letters 2013 v.15 no.24 pp. 6274-6277
- acetylcysteine, alpha-tocopherol, antioxidants, chemical reactions, delta-tocopherol, free radicals, glutathione peroxidase, mixing, models, moieties, tellurium
- In an effort to improve the chain-breaking capacity of the natural antioxidants, an octyltelluro group was introduced next to the phenolic moiety in β- and δ-tocopherol. The new vitamin E analogues quenched peroxyl radicals more efficiently than α-tocopherol and were readily regenerable by aqueous N-acetylcysteine in a simple membrane model composed of a stirring chlorobenzene/water two-phase system. The novel tocopherol analogues could also mimic the action of the glutathione peroxidase enzymes.