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General Synthetic Approach to Functionalized Dihydrooxepines

Author:
Nicolaou, K. C., Yu, Ruocheng, Shi, Lei, Cai, Quan, Lu, Min, Heretsch, Philipp
Source:
Organic letters 2013 v.15 no.8 pp. 1994-1997
ISSN:
1523-7052
Subject:
chemical structure, enols, oxidation, phosphates, regioselectivity
Abstract:
A three-step sequence to access functionalized 4,5-dihydrooxepines from cyclohexenones has been developed. This approach features a regioselective Baeyer–Villiger oxidation and subsequent functionalization via the corresponding enol phosphate intermediate.
Agid:
5786771