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Rhodium-Catalyzed Highly Enantioselective Arylation of Cyclic Diketimines: Efficient Synthesis of Chiral Tetrasubstituted 1,2,5-Thiadiazoline 1,1-Dioxides

Author:
Wang, Hui, Li, Yi, Xu, Ming-Hua
Source:
Organic letters 2014 v.16 no.15 pp. 3962-3965
ISSN:
1523-7052
Subject:
acids, arylation, chemical structure, enantioselectivity, ligands, olefin
Abstract:
A highly enantioselective rhodium-catalyzed arylation of cyclic diketimines with arylboronic acids was achieved under mild conditions by employing a simple, sulfinamide-based branched olefin ligand. This protocol provides an efficient access to valuable chiral tetrasubstituted 1,2,5-thiadiazoline 1,1-dioxides in high yields with excellent enantioselectivities of up to 99% ee.
Agid:
5787283