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Indium-Mediated Asymmetric Intramolecular Allenylation of N-tert-Butanesulfinyl Imines: Efficient and Practical Access to Chiral 3-Allenyl-4-aminochromanes

Author:
Su, Lin, Zhu, Ting-Shun, Xu, Ming-Hua
Source:
Organic letters 2014 v.16 no.16 pp. 4118-4121
ISSN:
1523-7052
Subject:
chemical structure, cyclization reactions, imines
Abstract:
An efficient method for the preparation of highly optically active 3-allenyl- and 3-vinyl-4-aminochromanes by In-mediated intramolecular cyclization has been developed. The synthetic utilities of the approach were demonstrated by the construction of various chiral polycyclic heterocycles, especially the interesting spiroheterocyclic compound 9 and steroid analogue 10.
Agid:
5787324