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Palladium-Catalyzed Regioselective Arylation of 1,1,3-Triaryl-2-azaallyl Anions with Aryl Chlorides

Author:
Li, Minyan, Berritt, Simon, Walsh, Patrick J.
Source:
Organic letters 2014 v.16 no.16 pp. 4312-4315
ISSN:
1523-7052
Subject:
anions, arylation, catalysts, catalytic activity, chemical structure, isomerization, ketimines, organochlorine compounds, palladium, regioselectivity
Abstract:
A regioselective arylation of 1,1,3-triaryl-2-azaallyl anions with aryl chlorides is described. The palladium-NIXANTPHOS-based catalyst affords diarylmethylamine derivatives in good yield and without product isomerization. A gram scale sequential one-pot ketimine synthesis/arylation protocol was also developed.
Agid:
5787374