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C–H Activation of Methyl Arenes in the MnO2-Mediated Aroylation of N-Chlorosulfoximines

Author:
Priebbenow, Daniel L., Bolm, Carsten
Source:
Organic letters 2014 v.16 no.6 pp. 1650-1652
ISSN:
1523-7052
Subject:
aromatic hydrocarbons, carbon-hydrogen bond activation, chemical reactions, chemical structure, manganese oxides, methodology
Abstract:
An investigation into the reactivity profile of N-halogenated sulfoximines has led to the development of a new method for the synthesis of N-aroylated sulfoximines. This protocol involves the manganese oxide promoted C–H activation of methyl arenes to form an aroyl intermediate which then reacts readily with N-chlorosulfoximines to form a series of valuable aroyl sulfoximine derivatives in high yields.
Agid:
5788385