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Asymmetric Chlorination/Ring Expansion for the Synthesis of α-Quaternary Cycloalkanones
- Yin, Qin, You, Shu-Li
- Organic letters 2014 v.16 no.6 pp. 1810-1813
- chemical structure, chlorination, enantioselectivity, organic compounds
- A highly enantioselective chlorination/ring expansion cascade for the construction of cycloalkanones with an all-carbon quaternary center was realized (up to 97% ee). Oxa-cyclobutanol substrates were employed for the first time in the ring expansion reactions, affording the functionalized dihydrofuranones in excellent enantioselectivity.