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2,2,2-Trifluoroethylation of Styrenes with Concomitant Introduction of a Hydroxyl Group from Molecular Oxygen by Photoredox Catalysis Activated by Visible Light

Author:
Li, Lun, Huang, Meiwei, Liu, Chao, Xiao, Ji-Chang, Chen, Qing-Yun, Guo, Yong, Zhao, Zhi-Gang
Source:
Organic letters 2015 v.17 no.19 pp. 4714-4717
ISSN:
1523-7052
Subject:
alcohols, catalytic activity, moieties, oxygen, redox reactions
Abstract:
The visible-light-induced photoredox difunctionalization reactions of styrenes with 1,1,1-trifluoro-2-iodoethane under an oxygen atmosphere in the presence of water give γ-trifluoromethyl alcohols. In this radical reaction, the oxygen atom in the product originates from molecular oxygen, and water is shown to be important to promote the reaction.
Agid:
5789637