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Regioselective Formation of 2,4,5-Trisubstituted Oxazoles through Transition-Metal Free Heterocyclization of 1,3-Diynes with N,O-Bis(trimethylsiyl)acetamide

Author:
Zhang, Liang, Zhao, Xiaoming
Source:
Organic letters 2015 v.17 no.2 pp. 184-186
ISSN:
1523-7052
Subject:
acetonitrile, chemical reactions, chemical structure, oxazoles, regioselectivity
Abstract:
Transition-metal free heterocyclization reaction of 1,3-diynes with N,O-bis(trimethylsiyl)acetamide was accomplished in the presence of t-BuOK and acetonitrile at 120 °C. This method regioselectively gave 2,4,5-trisubstituted oxazoles in yields up to 97%.
Agid:
5789694