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Solid-Supported Hydrazone of 4-(4′-Formyl-3′-methoxyphenoxy)butyric Acid As a New Traceless Linker for Solid-Phase Synthesis

Author:
Okorochenkov, Sergei, Burglova, Kristyna, Popa, Igor, Hlavac, Jan
Source:
Organic letters 2015 v.17 no.2 pp. 180-183
ISSN:
1523-7052
Subject:
boron compounds, butyric acid, chemical bases, chemical reactions, chemical structure, hydrazine, models
Abstract:
The use of a hydrazine derived from a backbone amide linker as a new hydrazone-based traceless linker for solid-phase organic synthesis is described. The stability of the linker was tested under various conditions, including treatment with acids, bases, and borohydrides. Final compounds can be released by selective cleavage using trimethylsilanolate. To demonstrate the versatility of the linker, the synthesis of a model compound under various reaction conditions was performed with good results.
Agid:
5789725