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Acyclic Cucurbit[n]uril Dendrimers
- Sigwalt, David, Ahlbrand, Sarah, Zhang, Mingming, Vinciguerra, Brittany, Briken, Volker, Isaacs, Lyle
- Organic letters 2015 v.17 no.23 pp. 5914-5917
- chemical reactions, chemical structure, dendrimers, gel electrophoresis, gene transfer, light scattering, plasmids, scanning electron microscopy
- The synthesis of acyclic cucurbit[n]uril dendrimers G1–G3 that bear four dendrons on their aromatic sidewalls via thiolate SN2 chemistry is reported. G1–G3 are polycationic and can bind to pEGFP plasmid DNA as shown by dynamic light scattering (DLS), gel electrophoresis, and scanning electron microscopy (SEM). The gene delivery ability of G1–G3 is presented.