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Copper-Catalyzed Regioselective Trifluoromethylthiolation of Pyrroles by Trifluoromethanesulfonyl Hypervalent Iodonium Ylide

Author:
Huang, Zhongyan, Yang, Yu-Dong, Tokunaga, Etsuko, Shibata, Norio
Source:
Organic letters 2015 v.17 no.5 pp. 1094-1097
ISSN:
1523-7052
Subject:
chemical reactions, chemical structure, pyrroles, reaction mechanisms, regioselectivity
Abstract:
The copper-catalyzed trifluoromethylthiolation of pyrroles with a trifluoromethanesulfonyl hypervalent iodonium ylide under mild conditions has been achieved. A broad set of pyrroles could be transformed to the corresponding products in moderate to excellent yields. The reaction mechanism is hypothesized.
Agid:
5790320