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Near-Infrared Triggered Upconversion Polymeric Nanoparticles Based on Aggregation-Induced Emission and Mitochondria Targeting for Photodynamic Cancer Therapy

Author:
Guan, Yue, Lu, Hongguang, Li, Wei, Zheng, Yadan, Jiang, Zhu, Zou, Jialing, Gao, Hui
Source:
ACS Applied Materials & Interfaces 2017 v.9 no.32 pp. 26731-26739
ISSN:
1944-8252
Subject:
acidity, apoptosis, biocompatibility, cell viability, cytotoxicity, energy, ethylene glycol, irradiation, mitochondria, nanoparticles, neoplasm cells, neoplasms, photochemotherapy, photosensitizing agents, polyethylene glycol, reactive oxygen species
Abstract:
Photodynamic therapy (PDT) is an auspicious strategy for cancer therapy by yielding reactive oxygen species (ROS) under light irradiation. Here, we have developed near-infrared (NIR) triggered polymer encapsulated upconversion nanoparticles (UCNPs) based on aggregation-induced emission (AIE) characteristics and mitochondria target ability for PDT. The coated AIE polymer as a photosensitizer can be photoactivated by the up-converted energy of UCNPs upon 980 nm laser irradiation, which could generate ROS efficiently in mitochondria and induce cell apoptosis. Moreover, a “sheddable” poly(ethylene glycol) (PEG) layer was easily conjugated at the surface of NPs. The pH-responsive PEG layer shields the surface positive charges and shows stronger protein-resistance ability. In the acidic tumor environment, PEGylated NPs lose the PEG layer and show the mitochondria-targeting ability by responding to tumor acidity. A cytotoxicity study indicated that these NPs have good biocompatibility in the dark but exert severe cytotoxicity to cancer cells, with only 10% cell viability, upon being irradiated with an NIR laser. The AIE nanoparticles are a good candidate for effective mitochondria targeting photosensitizer for PDT.
Agid:
5791293