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Ag2CO3/CA-AA-AmidPhos Multifunctional Catalysis in the Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides

Author:
Wang, Haifei, Deng, Qifu, Zhou, Zhipeng, Hu, Shunqin, Liu, Zhiguo, Zhou, Li-Yi
Source:
Organic letters 2016 v.18 no.3 pp. 404-407
ISSN:
1523-7052
Subject:
catalysts, catalytic activity, chemical structure, cycloaddition reactions, enantioselectivity, pyrrolidines
Abstract:
The new Ag₂CO₃/CA-AA-amidphos complexes have been demonstrated as highly efficient multifunctional catalysts in the asymmetric 1,3-dipolar cycloaddition of azomethine ylides. Under optimal conditions, highly functionalized endo-4 pyrrolidines were obtained with excellent yields (up to 99% yield) and enantioselectivities (up to 96% ee).
Agid:
5792274