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Cipacinoids A–D, Four Limonoids with Spirocyclic Skeletons from Cipadessa cinerascens

Author:
Yu, Jin-Hai, Liu, Qun-Fang, Sheng, Li, Wang, Guo-Cai, Li, Jia, Yue, Jian-Min
Source:
Organic letters 2016 v.18 no.3 pp. 444-447
ISSN:
1523-7052
Subject:
Cipadessa baccifera, X-ray diffraction, chemical reactions, chemical structure, limonoids, protein-tyrosine-phosphatase, spectral analysis
Abstract:
Four limonoids, cipacinoids A–D (1–4), with spirocyclic skeletons were isolated from Cipadessa cinerascens. It is particularly notable that compounds 1–3 had a 17S-configuration for the first time in the limonoid family. Their structures with absolute configurations were assigned by spectroscopic data, X-ray crystallography, and CD analysis. Compound 1 showed moderate protein tyrosine phosphatase 1B (PTP1B) inhibition.
Agid:
5792285