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Stereoselective Synthesis of Fused Aziridines via One-Pot Sequential Decarboxylative Mannich Reaction and Oxidative C–H Amination of Cyclic Imines with β-Ketoacids
- Lai, Bo-Nan, Qiu, Jian-Feng, Zhang, Heng-Xia, Nie, Jing, Ma, Jun-An
- Organic letters 2016 v.18 no.3 pp. 520-523
- amination, aziridines, chemical structure, diastereoselectivity, enantioselectivity, imines, stereoselective synthesis
- A novel one-pot sequential transformation via decarboxylative Mannich reaction (DMR) and oxidative C–H amination of cyclic imines with β-ketoacids is described. This methodology has been utilized to provide access to fused aziridines with excellent diastereoselectivity. Several examples of catalytic enantioselective sequential transformation are presented.