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One-Pot/Sequential Native Chemical Ligation Using Photocaged Crypto-thioester

Author:
Aihara, Keisuke, Yamaoka, Kosuke, Naruse, Naoto, Inokuma, Tsubasa, Shigenaga, Akira, Otaka, Akira
Source:
Organic letters 2016 v.18 no.3 pp. 596-599
ISSN:
1523-7052
Subject:
chemical reactions, moieties, organic compounds, peptides, proteins, synthesis, ultraviolet radiation
Abstract:
A practical and efficient methodology for the chemical synthesis of peptides/proteins using a one-pot/sequential ligation is described. It features the use of photocleavable S-protection on an N-sulfanylethylaniline moiety. Removal of the S-protecting ligated materials under UV irradiation provides a readily usable mixture for subsequent native chemical ligation.
Agid:
5792321